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Image Search Results
Journal: The Journal of Experimental Medicine
Article Title: Dietary copper supplementation reverses hypertrophic cardiomyopathy induced by chronic pressure overload in mice
doi: 10.1084/jem.20061943
Figure Lengend Snippet: Effect of Cu supplementation on AAC-suppressed VEGF, angiogenesis, and cardiac Cu concentrations. (A) Myocardial capillary density detected by CD31 staining. Bars, 50 μm. (B) Quantitative analysis of capillary density using a computer-assisted image analyzer (SigmaScan Pro5.0; SPSS, Inc.). Three fields at 200× magnification per heart were analyzed and six mice in each group were examined for the calculation. (C) Western blot analysis of VEGF levels in the heart tissue. (D) AAC-induced decreases in cardiac Cu concentrations 4 wk after AAC and the effect of Cu supplementation. (E) AAC-induced depression of cardiac CCO activity (CCO/CS ratio) 4 or 8 wk after AAC and the effect of Cu supplementation. *, Significantly different from sham-operated controls (P < 0.05, n = 6). # , Significantly different from AAC-treated mice fed 6 ppm Cu diet for 4 wk (P < 0.05, n = 6).
Article Snippet: The capillary density was assessed by a computer-assisted image analyzer (
Techniques: Staining, Western Blot, Activity Assay