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Effect of Cu supplementation on AAC-suppressed VEGF, angiogenesis, and cardiac Cu concentrations. (A) Myocardial capillary density detected by CD31 staining. Bars, 50 μm. (B) Quantitative analysis of capillary density using a computer-assisted image analyzer (SigmaScan <t>Pro5.0;</t> SPSS, Inc.). Three fields at 200× magnification per heart were analyzed and six mice in each group were examined for the calculation. (C) Western blot analysis of VEGF levels in the heart tissue. (D) AAC-induced decreases in cardiac Cu concentrations 4 wk after AAC and the effect of Cu supplementation. (E) AAC-induced depression of cardiac CCO activity (CCO/CS ratio) 4 or 8 wk after AAC and the effect of Cu supplementation. *, Significantly different from sham-operated controls (P < 0.05, n = 6). # , Significantly different from AAC-treated mice fed 6 ppm Cu diet for 4 wk (P < 0.05, n = 6).
Computer Assisted Image Analyzer, supplied by SPSS Inc, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/product/image+analyzer+sigmascan+pro+5+0/pmc02137915-129-10-12?v=SPSS+Inc
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Effect of Cu supplementation on AAC-suppressed VEGF, angiogenesis, and cardiac Cu concentrations. (A) Myocardial capillary density detected by CD31 staining. Bars, 50 μm. (B) Quantitative analysis of capillary density using a computer-assisted image analyzer (SigmaScan <t>Pro5.0;</t> SPSS, Inc.). Three fields at 200× magnification per heart were analyzed and six mice in each group were examined for the calculation. (C) Western blot analysis of VEGF levels in the heart tissue. (D) AAC-induced decreases in cardiac Cu concentrations 4 wk after AAC and the effect of Cu supplementation. (E) AAC-induced depression of cardiac CCO activity (CCO/CS ratio) 4 or 8 wk after AAC and the effect of Cu supplementation. *, Significantly different from sham-operated controls (P < 0.05, n = 6). # , Significantly different from AAC-treated mice fed 6 ppm Cu diet for 4 wk (P < 0.05, n = 6).
Image Analysis Software Sigmascan Pro 5.0, supplied by HULINKS Inc, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/product/image+analyzer+sigmascan+pro+5+0/pmc11968064-46-5-11?v=HULINKS+Inc
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Effect of Cu supplementation on AAC-suppressed VEGF, angiogenesis, and cardiac Cu concentrations. (A) Myocardial capillary density detected by CD31 staining. Bars, 50 μm. (B) Quantitative analysis of capillary density using a computer-assisted image analyzer (SigmaScan <t>Pro5.0;</t> SPSS, Inc.). Three fields at 200× magnification per heart were analyzed and six mice in each group were examined for the calculation. (C) Western blot analysis of VEGF levels in the heart tissue. (D) AAC-induced decreases in cardiac Cu concentrations 4 wk after AAC and the effect of Cu supplementation. (E) AAC-induced depression of cardiac CCO activity (CCO/CS ratio) 4 or 8 wk after AAC and the effect of Cu supplementation. *, Significantly different from sham-operated controls (P < 0.05, n = 6). # , Significantly different from AAC-treated mice fed 6 ppm Cu diet for 4 wk (P < 0.05, n = 6).
Sigmascan Pro 5.0, supplied by SPSS Inc, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/product/image+analyzer+sigmascan+pro+5+0/pm25039212-83-13-16?v=SPSS+Inc
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Effect of Cu supplementation on AAC-suppressed VEGF, angiogenesis, and cardiac Cu concentrations. (A) Myocardial capillary density detected by CD31 staining. Bars, 50 μm. (B) Quantitative analysis of capillary density using a computer-assisted image analyzer (SigmaScan <t>Pro5.0;</t> SPSS, Inc.). Three fields at 200× magnification per heart were analyzed and six mice in each group were examined for the calculation. (C) Western blot analysis of VEGF levels in the heart tissue. (D) AAC-induced decreases in cardiac Cu concentrations 4 wk after AAC and the effect of Cu supplementation. (E) AAC-induced depression of cardiac CCO activity (CCO/CS ratio) 4 or 8 wk after AAC and the effect of Cu supplementation. *, Significantly different from sham-operated controls (P < 0.05, n = 6). # , Significantly different from AAC-treated mice fed 6 ppm Cu diet for 4 wk (P < 0.05, n = 6).
Sigmascan Pro 5.0, supplied by SSPS Inc, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/product/image+analyzer+sigmascan+pro+5+0/pm16444734-103-9-12?v=SSPS+Inc
Average 90 stars, based on 1 article reviews
sigmascan pro 5.0 - by Bioz Stars, 2026-08
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Image Search Results


Effect of Cu supplementation on AAC-suppressed VEGF, angiogenesis, and cardiac Cu concentrations. (A) Myocardial capillary density detected by CD31 staining. Bars, 50 μm. (B) Quantitative analysis of capillary density using a computer-assisted image analyzer (SigmaScan Pro5.0; SPSS, Inc.). Three fields at 200× magnification per heart were analyzed and six mice in each group were examined for the calculation. (C) Western blot analysis of VEGF levels in the heart tissue. (D) AAC-induced decreases in cardiac Cu concentrations 4 wk after AAC and the effect of Cu supplementation. (E) AAC-induced depression of cardiac CCO activity (CCO/CS ratio) 4 or 8 wk after AAC and the effect of Cu supplementation. *, Significantly different from sham-operated controls (P < 0.05, n = 6). # , Significantly different from AAC-treated mice fed 6 ppm Cu diet for 4 wk (P < 0.05, n = 6).

Journal: The Journal of Experimental Medicine

Article Title: Dietary copper supplementation reverses hypertrophic cardiomyopathy induced by chronic pressure overload in mice

doi: 10.1084/jem.20061943

Figure Lengend Snippet: Effect of Cu supplementation on AAC-suppressed VEGF, angiogenesis, and cardiac Cu concentrations. (A) Myocardial capillary density detected by CD31 staining. Bars, 50 μm. (B) Quantitative analysis of capillary density using a computer-assisted image analyzer (SigmaScan Pro5.0; SPSS, Inc.). Three fields at 200× magnification per heart were analyzed and six mice in each group were examined for the calculation. (C) Western blot analysis of VEGF levels in the heart tissue. (D) AAC-induced decreases in cardiac Cu concentrations 4 wk after AAC and the effect of Cu supplementation. (E) AAC-induced depression of cardiac CCO activity (CCO/CS ratio) 4 or 8 wk after AAC and the effect of Cu supplementation. *, Significantly different from sham-operated controls (P < 0.05, n = 6). # , Significantly different from AAC-treated mice fed 6 ppm Cu diet for 4 wk (P < 0.05, n = 6).

Article Snippet: The capillary density was assessed by a computer-assisted image analyzer (SigmaScan Pro5.0; SPSS, Inc.).

Techniques: Staining, Western Blot, Activity Assay